A simple, accurate, precise and specific spectrophotometric method has been developed for simultaneous determination of piroxicam and paracetamol in their combined tablet dosage form by using 0.1M HCl as a solvent. The method is first order derivative method in which absorption at 313.12 nm (zero cross point of paracetamol) was used for quantification of piroxicam and 259.24 nm (zero cross point of piroxicam) for quantification of paracetamol. The method follows Beer’s linearity in the range of 0.8-10 μg/ml for piroxicam and 8-32 μg/ml for paracetamol. The mean % recoveries were found to be in the range of 98.33–101.38% and 99.55–100.28% for piroxicam and paracetamol respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of piroxicam and paracetamol in their combined Tablet dosage form.
Loading....